Reference of 51618-29-2, An article , which mentions 51618-29-2, molecular formula is C7H4ClNS2. The compound – 6-Chlorobenzo[d]thiazole-2-thiol played an important role in people’s production and life.
Design, synthesis and biological evaluation of new rhodacyanine analogues as potential antitumor agents
In an attempt to develop potent antitumor agents, new rhodacyanine analogues containing the pyridinium ring (5a-5h), the isoquinolinium ring (6a-6c) and the quinolinium ring (7a-7e) linked to the rhodanine ring via N-N covalent bond were designed, synthesized and evaluated for antitumor activity against human lung cancer cell line (H460) by MTT assay in vitro. Most of the tested compounds showed enhanced antitumor activity with IC50 values ranging from 0.006 to 9.2 mumol/L as compared to the lead compound MKT-077. Among them, the most promising compound 7d (IC50 = 0.006 mumol/L) was 216.7 times more active than MKT-077 (IC50 = 1.3 mumol/L). The preliminary structure-activity relationship of the target compounds was discussed.
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Reference：
Thiazole | C3H7002NS – PubChem,
Thiazole | chemical compound | Britannica