Related Products of 656-53-1. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 656-53-1, Name is 2-(4-Methylthiazol-5-yl)ethyl acetate
Cobalt-Catalyzed Oxidative C?H/C?H Cross-Coupling between Two Heteroarenes
The first example of cobalt-catalyzed oxidative C?H/C?H cross-coupling between two heteroarenes is reported, which exhibits a broad substrate scope and a high tolerance level for sensitive functional groups. When the amount of Co(OAc)2?4 H2O is reduced from 6.0 to 0.5 mol %, an excellent yield is still obtained at an elevated temperature with a prolonged reaction time. The method can be extended to the reaction between an arene and a heteroarene. It is worth noting that the Ag2CO3oxidant is renewable. Preliminary mechanistic studies by radical trapping experiments, hydrogen/deuterium exchange experiments, kinetic isotope effect, electron paramagnetic resonance (EPR), and high resolution mass spectrometry (HRMS) suggest that a single electron transfer (SET) pathway is operative, which is distinctly different from the dual C?H bond activation pathway that the well-described oxidative C?H/C?H cross-coupling reactions between two heteroarenes typically undergo.
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Reference：
Thiazole | C3H923NS – PubChem,
Thiazole | chemical compound | Britannica