566169-93-5, Name is 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol, molecular formula is C14H12N2OS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 566169-93-5, Safety of 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol
Synthesis and monkey-PET study of (R)- and (S)-18F-labeled 2-arylbenzoheterocyclic derivatives as amyloid probes with distinctive in vivo kinetics
This study describes an effective strategy to improve pharmacokinetics of Abeta imaging agents, offering a novel class of (R)- and (S)-18F-labeled 2-arylbenzoheterocyclic derivatives which bear an additional chiral hydroxyl group on the side chain. These ligands displayed binding abilities toward Abeta aggregates with Ki values ranging from 3.2 to 195.6 nM. Chirality-related discrepancy was observed in biodistribution, and (S)-2-phenylbenzoxazole enantiomers exhibited vastly improved brain clearance with washout ratios higher than 20. Notably, (S)-[18F]28 possessed high binding potency (Ki = 7.6 nM) and exceptional brain kinetics (9.46% ID/g at 2 min, brain2min/brain60min = 27.8) that is superior to well-established [18F]AV45. The excellent pharmacokinetics and low nonspecific binding of (S)-[18F]28 were testified by dynamic PET/CT scans in monkey brains. In addition, (S)-[18F]28 clearly labeled Abeta plaques both in vitro and ex vivo. These results might qualify (S)-[18F]28 to detect Abeta plaques with high signal-to-noise ratio.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Safety of 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol. In my other articles, you can also check out more blogs about 566169-93-5
Reference：
Thiazole | C3H427NS – PubChem,
Thiazole | chemical compound | Britannica