Synthetic Route of 169260-97-3. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 169260-97-3, Name is 5-(Trifluoromethyl)thiazol-2-amine
The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators
Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor for which only short-chain fatty acids (SCFAs) have been reported as endogenous ligands. We describe the discovery and optimization of phenylacetamides as allosteric agonists of FFA2. These novel ligands can suppress adipocyte lipolysis in vitro and reduce plasma FFA levels in vivo, suggesting that these allosteric modulators can serve as pharmacological tools for exploring the potential function of FFA2 in various disease conditions.
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Reference：
Thiazole | C3H6035NS – PubChem,
Thiazole | chemical compound | Britannica