Synthetic Route of 169260-97-3. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 169260-97-3, Name is 5-(Trifluoromethyl)thiazol-2-amine. In a document type is Patent, introducing its new discovery.
Process for preparing pyrrolidinones
A process for the preparation of a compound of general formula II: STR1 wherein R1 is hydrogen, or C1 -C10 hydrocarbyl or heterocyclyl having 3 to 8 ring atoms, either of which may optionally be substituted; each R2, R3, R4 and R5 is independently hydrogen or C1 -C4 alkyl; A is an optionally substituted aromatic or heteroaromatic ring system; and R21 is hydrogen, halogen, OH or OCONHR1, wherein R1 is as defined above; the process comprising cyclizing a compound of general formula III: STR2 wherein A, R2, R3, R4, R5 and R21 are as defined in general formula II and R25 is a leaving group such as a halogen atom; under basic conditions.
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Reference：
Thiazole | C3H6039NS – PubChem,
Thiazole | chemical compound | Britannica