2103-99-3, 4-(4-Chlorophenyl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A solution of 2-amino-4-phenylthiazole 6a (0.530 g, 3 mmol) and Et3N (560 muL, 4 mmol) in dichloromethane (15 mL) was cooled to 0-5 C in an ice-bath and stirred for 30 min. 2-Chloroacetyl chloride (578 muL, 6.6 mmol) in dry dichloromethane (1.5 mL) was then added slowly, and the reaction mixture was allowed to warm to room temperature and stirred until the amine was completely consumed (ca. 1 h, as monitored by TLC). The reaction mixture was diluted with dichloromethane and washed successively with water and saturated brine. The organic layer was dried over anhydrous Na2SO4, the solvent was removed under reduced pressure and the residue was recrystallised from ethanol to give compound 7a (0.413 g, 54percent) as light-grey crystals, mp 170-171 oC (Lit.18,20,26 171-173 oC). The remaining analogues were obtained similarly [7b (100percent) as a brown solid, mp 194-195 oC (Lit.27 mp not cited); 7c (64percent) as a brown solid, mp 241-243 oC (Lit.27 mp not cited); 7d (64percent) as a brown solid, mp 135-137 oC (Lit.28 135 oC); 7e (0.262 g, 88percent) as a yellow solid, mp 174-176 C (Lit.29 175 oC); 7f (70percent) as a light-brown solid, mp 213-216 oC (Lit.30 216 oC)., 2103-99-3
The synthetic route of 2103-99-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Olawode, Emmanuel O.; Tandlich, Roman; Prinsloo, Earl; Isaacs, Michelle; Hoppe, Heinrich; Seldon, Ronnett; Warner, Digby F.; Steenkamp, Vanessa; Kaye, Perry T.; Arkivoc; vol. 2018; 7; (2018); p. 110 – 118;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica