Can You Really Do Chemisty Experiments About 6-Nitrobenzo[d]thiazole-2(3H)-thione

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Product Details of 4845-58-3. In my other articles, you can also check out more blogs about 4845-58-3

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4845-58-3, Name is 6-Nitrobenzo[d]thiazole-2(3H)-thione, molecular formula is C7H4N2O2S2. In a Article,once mentioned of 4845-58-3, Product Details of 4845-58-3

Whereas the role of mammalian thioredoxin (Trx) as an intracellular protein cofactor is widely appreciated, its function in the extracellular environment is not well-understood. Only few extracellular targets of Trx-mediated thiol-disulfide exchange are known. For example, Trx activates extracellular transglutaminase 2 (TG2) via reduction of an intramolecular disulfide bond. Because hyperactive TG2 is thought to play a role in various diseases, understanding the biological role of extracellular Trx may provide critical insight into the pathogenesis of these disorders. Starting from a clinical-stage asymmetric disulfide lead, we have identified analogs with >100-fold specificity for Trx. Structure-activity relationship and computational docking model analyses have provided insights into the features important for enhancing potency and specificity. The most active compound identified had an IC 50 below 0.1 muM in cell culture and may be appropriate for in vivo use to interrogate the role of extracellular Trx in health and disease.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Product Details of 4845-58-3. In my other articles, you can also check out more blogs about 4845-58-3

Reference:
Thiazole | C3H7341NS – PubChem,
Thiazole | chemical compound | Britannica