Application of 64485-82-1. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 64485-82-1, Name is (Z)-Ethyl 2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetate. In a document type is Article, introducing its new discovery.
Based on the structural characteristics of aztreonam (AZN) and its target PBP3, a series of new monobactam derivatives bearing various substituents on oxime residue were prepared and evaluated for their antibacterial activities against susceptible and resistant Gram-negative bacteria. Among them, compounds 8p and 8r displayed moderate potency with MIC values of 0.125?32 mug/mL against most tested Gram-negative strains, comparable to AZN. Meanwhile, the combination of 8p and 8r with avibactam as a beta-lactamases inhibitor, in a ratio of 1:16, showed a promising synergistic effect against both ESBLs- and NDM-1-producing K. pneumoniae, with significantly reduced MIC values up to 8-fold and >256-fold respectively. Furthermore, both of them demonstrated excellent safety profiles both in vitro and in vivo. The results provided powerful information for further structural optimization of monobactam antibiotics to fight beta-lactamase-producing resistant Gram-negative bacteria.
If you are interested in 64485-82-1, you can contact me at any time and look forward to more communication.Application of 64485-82-1
Reference：
Thiazole | C3H145NS – PubChem,
Thiazole | chemical compound | Britannica