With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.160844-75-7,Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate,as a common compound, the synthetic route is as follows.
Preparation of febuxostat without isolation of intermediate ethyl-2-(3-cyano-4- isobutoxyphenyl)-4-methyl thiazole-5-carboxylate 3-cyano-4-isobutoxyphenyl boronic acid (5.0 gms/0.02283 moles), ethyl-2-bromo-4-methylthiazole-5-carboxylate (5.70 gms/0.02289 moles) and 50 ml of 2M aqueous sodium carbonate solution were charged in 75 ml toluene, followed by tetrakis (triphenyl phosphine) palladium (1.5 gms). The resultant mixture was stirred at 70- 75¡ãC for 1 hour. The reaction mass was cooled to 25¡ãC and extracted in ethyl acetate (30ml). The organic layer was washed with brine, dried over anhydrous sodium sulphate and the clear filtrate was distilled off completely.The residue was stirred in 40 ml THF under inert atmosphere. To the reaction mass, 2N NaOH (11 ml) was slowly added at 25-30¡ãC and stirred further at reflux for 5 hours. The reaction mass was cooled to 25¡ãC and filtered through celite. The reaction mass was acidified with diluted concentrated HCI. The reaction mass was further stirred for 30 minutes. The resulting solid was isolated by filtration, washed with water until a neutral pH and dried under vacuum to yield 3.3 gms of the titled compound. Efficiency: 72percent, 160844-75-7
The synthetic route of 160844-75-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CIPLA LIMITED; BIRARI, Dilip, Ramdas; RAO, Dharmaraj, Ramachandra; KANKAN, Rajendra, Narayanrao; CURTIS, Philip, Anthony; WO2011/73617; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica