With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.
EXAMPLE 15 Preparation of Ethyl N-(4,5,6,7-Tetrahydrobenzothiazol-2-yl)carbamate 2-Amino-4,5,6,7-tetrahydrobenzothiazole (12.3 grams; 0.08 mol) dissolved in pyridine (50 ml.) was charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and addition funnel. Ethyl chloroformate (12 ml; 0.11 mol) was added dropwise to the reaction mixture with stirring and cooling. After the addition was completed the reaction mixture was allowed to warm to room temperature and stirring was continued for a period of about 1 hour. After this time the reaction mixture was poured into ice water (50 mol.) to form a precipitate. The precipitate was recovered by filtration, washed with water four times dried and recrystallized from ethanol to yield the desired product ethyl N-(4,5,6,7-tetrahydrobenzothiazol-2-yl)carbamate; (16.7 grams); melting point 182-184 C. The structure of the product was verified by infrared and NMR spectroscopy., 2933-29-1
As the paragraph descriping shows that 2933-29-1 is playing an increasingly important role.
Reference£º
Patent; Velsicol Chemical Corporation; US4319914; (1982); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica