16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole, molecular formula is C14H11NS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 16112-21-3, Quality Control of: 2-(4-Methylphenyl)benzothiazole
The invention feature series of benzothiazole derivatives as potent immunosuppressive and antiinflammatory agents. Eight compounds 2, 4, 5, 8, 9, 10, 12, and 18 showed potent inhibitory activity on PHA-activated T-cell proliferation. Compounds 2, 4, 8, and 18 were found to have a potent inhibitory activity with IC50 values ranging <1.0-2.9 mug/mL against IL-2. Studies on innate immune response revealed that compounds 2, 8, 9, and 10 have significant suppressive effect on ROS production with an IC50 values 1.9, <1, 3.7 and 1.1 mug/mL, respectively. The LPS-induced nitrites in J774 macrophages cell line was inhibited by 4, 8, 9, and 18 at a concentration of 25 mug/mL (56-91%). In addition compounds 5, 8, 12, and 18 showed potent suppression on interleukin 4 (IL-4), particularly 9 (IC50<1 mug/mL). No cytotoxicity was found except for compound 9 and 18 (11.4 and 10.4 mug/mL IC50), respectively. Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 2-(4-Methylphenyl)benzothiazole. In my other articles, you can also check out more blogs about 16112-21-3
Reference：
Thiazole | C3H647NS – PubChem,
Thiazole | chemical compound | Britannica