The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.59608-97-8, Name is 4-(Chloromethyl)thiazol-2-amine hydrochloride, molecular formula is C4H6Cl2N2S. In a Article，once mentioned of 59608-97-8, Recommanded Product: 4-(Chloromethyl)thiazol-2-amine hydrochloride
Coupling reactions involving non-sulfonated C-O electrophiles provide a promising method for forming C-C bonds, but the incorporation of functionalized or secondary alkyl groups remains a challenge due to the requirement for well-defined alkylmetal species. In this study, we report a reductive nickel-catalyzed cross-coupling of benzyl oxalates with alkyl bromides, using oxalate as a new leaving group. A broad range of highly functionalized alkyl units (such as functional groups: alkyl chloride, alcohol, aldehyde, amine, amide, boronate ester, ether, ester, heterocycle, phosphonate, strained ring) were efficiently incorporated at the benzylic position. The utility of this synthetic method was further demonstrated by late-stage modification of complex bioactive compounds. Preliminary mechanistic experiments revealed that a radical process might be involved in the reaction.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 4-(Chloromethyl)thiazol-2-amine hydrochloride, you can also check out more blogs about59608-97-8
Reference：
Thiazole | C3H4721NS – PubChem,
Thiazole | chemical compound | Britannica