With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.
615-21-4, 20.0 g (0.12 mol) of 2-hydrazinobenzothiazole and 200 ml of N, N-dimethylformamide (DMF) were placed in a four-neck reactor equipped with a thermometer in a nitrogen stream to obtain a uniform solution . To this solution, 83.6 g (0.61 mol) of potassium carbonate and 30.8 g (0.15 mol) of 1-iodohexane were added and the whole of the mixture was stirred at 50 C. for 7 hours. After completion of the reaction, the reaction solution was cooled to 20 C., then the reaction solution was poured into 1000 ml of water and extracted with 800 ml of ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and sodium sulfate was filtered off. Ethyl acetate was distilled off from the filtrate under reduced pressure on a rotary evaporator to obtain a yellow solid. This yellow solid was purified by silica gel column chromatography (n-hexane: ethyl acetate = 75: 25) to obtain 21.0 g of compound (IIa) as a white solid (yield: 69.6%).
As the paragraph descriping shows that 615-21-4 is playing an increasingly important role.
Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; (21 pag.)JP2016/190828; (2016); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica