With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.440100-94-7,2-Bromothiazole-5-carbonitrile,as a common compound, the synthetic route is as follows.
2) 2-Bmothiazole-5-carbonitrile (955 mg, 5.05 mmol) obtained in (1) and diisopropylethylamine (1.80 mL, 10.1 mmol) were dissolved in 1,4-dioxane (20 mL). To the solution was added 1,2-amino-2-methylpropane (1.10 mL, 10.1 mmol) under ice-cooling, and the mixture was allowed to react at room temperature overnight. After the reaction mixture was concentrated, the residue was purified by silica gel column chromatography (chloroform/methanol=10/1) to obtain the title compound (895 mg, 4.57 mmol).yield: 90%<1>H NMR (CDCl3) delta (ppm): 7.64 (1H, s), 3.15 (2H, s), 1.21 (6H, s).APCIMS (m/z): 197 (M + H)<+>
440100-94-7, The synthetic route of 440100-94-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; KYOWA HAKKO KOGYO CO., LTD.; EP1354882; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica