121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
121-66-4, 5-Nitro-2-aminothiazole (1 eq)And triethylamine (1.2 eq) were dissolved in CH 2 Cl 2,Chloroacetyl chloride (1.2 eq) was added dropwise at 0 C,After the addition was completed, the reaction was continued for 5h,The reaction was checked by TLC, leaving no residue of the starting material and stopping the reaction.To the reaction mixture were added 100 ml of distilled water, the aqueous phase was extracted three times with CH 2 Cl 2 (3 ¡Á 100 ml), the organic phase was washed twice with saturated NaCl (2 ¡Á 100 ml), dried over anhydrous magnesium sulfate and then concentrated by evaporation to obtain a crude product. The crude product was purified by column chromatography on silica gel (methylene chloride: methanol = 150: 1, v: v) to give pure yellow solid in 82% yield.
As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.
Reference£º
Patent; Shandong University; Hu Wei; Li Xun; Wang Chuandong; Li Xing; Wang Yan; Wu Yibo; Lu Di; Wu Hao; Zhang Yunxi; (8 pag.)CN106588813; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica