913836-22-3, Methyl 5-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
913836-22-3, To a stirred solution of methyl 5-bromo-1 ,3-thiazole-4-carboxylate (5.00 g, 22.52 mmol) in THF (80 mL) was added an aq. solution of LiOH.H20 (2.70 g, 1 12.58 mmol) in H20 (20 mL). The reaction mixture was stirred at room temperature for 18 h. DCM (50 mL) and H2O (20 mL) were then added and the reaction mixture acidified to pH~2 with 2 M aqueous HCI, followed by extraction with DCM (3 chi 20 mL). The combined organic extracts were washed with brine (20 mL), dried over MgSCU, filtered and concentrated under reduced pressure to give 5-bromo-1 ,3-thiazole-4-carboxylic acid (3.09 g, 66 % yield) as a yellow solid, which was used without further purification. LC-MS (Method D) 208.3/210.3 [M+H]+; RT 1.36 min
The synthetic route of 913836-22-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; REDX PHARMA PLC; STOKES, Neil; (163 pag.)WO2017/46603; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica