A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 439134-78-8, Name is 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole, molecular formula is C12H9BrF3NS. In a Patent，once mentioned of 439134-78-8, name: 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole
The invention discloses a selective PPAR delta agonist GW501516 preparation method, which belongs to the technical field of synthesis of pharmaceutical intermediates. In order to O-methyl phenol as raw materials, and the iodine/potassium bromide through the oxidizing agent to obtain the 4 – iodo/bromo – 2 – methyl phenol, then with the chloro/bromo acetic acid obtained through the reaction of tert-butyl (4 – bromo/iodo – 2 – methyl-phenoxy) – butyl […], followed by Grignard reagent exchange, sequentially with the powder and 5 – (bromomethyl) – 4 – methyl – 2 – [4 – (trifluoromethyl) phenyl] – 1, 3 – thiazole reaction to obtain 2 – [2 – methyl – 4 – – [[ [4 – methyl – 2 – [4 – (trifluoromethyl) phenyl] – 5 – thiazolyl] methyl] thio] phenoxy] acetic acid tert-butyl, finally hydrolyzed to obtain the selective PPAR delta agonist GW501516. The process of the invention the operation is simple, mild condition, raw materials are cheap and easy to obtain, for the synthesizing amplifying of the medicament provides reference. (by machine translation)
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole. In my other articles, you can also check out more blogs about 439134-78-8
Reference：
Thiazole | C3H5978NS – PubChem,
Thiazole | chemical compound | Britannica