With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35272-15-2,2-Methylthiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
1.00 g (6.99 mmol) of 2-methyl-1,3-thiazole-4-carboxylic acid was added to 3.62 g of polyphosphoricacid. 0.64 g (6.99 mmol) of hydrazinecarbothioamide was added portionwise. It was stirred for 1 h at140 ¡ãC. After cooling down to 70 ¡ãC, water (10 mL) was added dropwise. After cooling to 0 ¡ãC,aqueous ammonium hydroxide solution (25percent, 8 mL) was added till a pH value of 12 was achieved. The precipitate was collected by filtration, washed with water and dried under reduced pressure at 50 ¡ãC affording 821 mg (59percent of theory) of the title compound.?H-NMR (400MHz, DMSO-d6): 6 [ppm]= 2.69 (s, 3H), 7.33 (s, 2H), 7.96 (s, 1H). LC-MS (Method 4): R = 0.65 mm; MS (ESIpos): m/z = 199 [M+H].
35272-15-2, The synthetic route of 35272-15-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; THEDE, Kai; BENDER, Eckhard; SCOTT, William; RICHTER, Anja; ZORN, Ludwig; LIU, Ningshu; MOeNNING, Ursula; SIEGEL, Franziska; GOLZ, Stefan; HAeGEBARTH, Andrea; LIENAU, Philip; PUEHLER, Florian; BASTING, Daniel; SCHNEIDER, Dirk; MOeWES, Manfred; GEISLER, Jens; WO2015/140195; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica