A new application about 41731-23-1

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: 2-Bromo-5-methylthiazole. In my other articles, you can also check out more blogs about 41731-23-1

41731-23-1, Name is 2-Bromo-5-methylthiazole, molecular formula is C4H4BrNS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 41731-23-1, name: 2-Bromo-5-methylthiazole

We have discovered a novel series of 4-Azetidinyl-1-Aryl-cyclohexanes as CCR2 antagonists. Divergent SAR studies on hCCR2 and hERG activities led to the discovery of compound 8d, which displayed good hCCR2 binding affinity (IC 50, 37 nM) and potent functional antagonism (chemotaxis IC 50, 30 nM). It presented an IC50 of >50 muM in inhibition of the hERG channel and had no effect on the QTc interval up to 10 mg/kg (i.v.) in anesthetized guinea pig and dog CV studies. It also displayed high selectivity over other chemokine receptors and GPCRs, and amendable oral bioavailability in dogs and primates. In a thioglycollate-induced inflammation model in hCCR2KI mice, it had ED50 of 3 mg/kg on inhibition of the influx of leukocytes, monocytes/macrophages, and T-lymphocytes.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: 2-Bromo-5-methylthiazole. In my other articles, you can also check out more blogs about 41731-23-1

Reference：
Thiazole | C3H2560NS – PubChem,
Thiazole | chemical compound | Britannica