1383816-29-2, rel-2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The previously described Example 1- lB, 2-(3-((5-cyclopropyl-3-(2- (trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4- fluorobenzo[d]thiazole-6-carboxylic acid (20 mg, 0.033 mmol), was suspended in methylene chloride (0.6 mL), cooled to 0 C and treated with Nu,Nu-diisopropylethylamine (aprox. 10 uL, 0.07 mmol) and oxalyl chloride (10 uL, 0.10 mmol). After 20 minutes the reaction was concentrated in vacuo to a reddish colored residue, suspended in THF (0.5 mL) and then treated with 10 N ammonium hydroxide. After 1 hr of stirring, the reaction was diluted with ethyl acetate (1 mL), and water washed (2 x 0.5 mL). The resulting organic extract were concentrated to dryness, re-diluted with MeOH (2 mL), and directly purified using mass-directed reverse phase HPLC, using gradient of 30 to 90 % acetonitrile/water, and 0.05 % TFA as modifier. All product fractions were cold vacuum concentrated and free-based using an SPE polymer support cartridge and MeOH (2 mL) mobilizing solvent (product SPE PLHC03 MP part no PL3540- C603). All resulting methanol effluent was concentrated to furnish the title compound as a white powder, 14 mg (70 %). MS m/z 603.1 (M + 1)., 1383816-29-2
The synthetic route of 1383816-29-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; IRM LLC; TULLY, David C.; RUCKER, Paul Vincent; ALPER, Phillip B.; MUTNICK, Daniel; CHIANELLI, Donatella; WO2012/87519; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica