Downstream synthetic route of 41731-83-3

As the paragraph descriping shows that 41731-83-3 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.,41731-83-3

Step 1: ethyl 2-pyridin-2-yl-1,3-thiazole-5-carboxylate A mixture of bromo(pyridine-2-yl)zinc (0.5 M in THF, 1.27 mL), ethyl 2-bromo-1,3-thiazole-5-carboxylate (0.063 mL, 0.42 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.02 g, 0.02 mmol) in 1,4-dioxane (3 mL) and water (0.03 mL) was subjected to MWI at 120 C. for 10 min. The reaction mixture was diluted with water and extracted with EtOAc. The organic solutions were combined, dried over Na2SO4, filtered, and concentrated to give ethyl 2-pyridin-2-yl-1,3-thiazole-5-carboxylate (0.12 g) which was used without further purification. LCMS: (FA) ES+235.

As the paragraph descriping shows that 41731-83-3 is playing an increasingly important role.

Reference£º
Patent; Millennium Pharmaceuticals, Inc.; US2008/171754; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica