A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 3034-22-8, Name is 5-Bromothiazol-2-amine, molecular formula is C3H3BrN2S. In a Article，once mentioned of 3034-22-8, Computed Properties of C3H3BrN2S
We have reported potent peptidic and non-peptidic BACE1 inhibitors with a hydroxymethylcarbonyl (HMC) isostere as a substrate transition-state mimic. However, our potent inhibitors possess a tetrazole ring at the P 1? position. It is desirable that central nervous system (CNS) drugs do not possess an acidic moiety. In this study, we synthesized non-acidic BACE1 inhibitors with heterocyclic derivatives at the P1? position. KMI-1764 (27) exhibited potent inhibitory activity (IC50 = 27 nM). Interestingly, these non-acidic inhibitors tended to follow the quantitative structure-activity relationship (QSAR) equation and interacted with BACE1-Arg235 in the binding model.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Computed Properties of C3H3BrN2S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3034-22-8, in my other articles.
Reference：
Thiazole | C3H6163NS – PubChem,
Thiazole | chemical compound | Britannica