Synthetic Route of 1603-91-4. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1603-91-4, Name is 4-Methylthiazol-2-amine
Based on the multi-target strategy to treat type 2 diabetes mellitus (T2DM), glucokinase/peroxisome proliferator-activated receptor gamma (GK/PPARgamma) dual-target molecules were constructed by the rational combination of pharmacophores from known GK activators and PPARgamma agonists. A series of dual-target agents were designed and synthesized, and their capacities to induce GK and PPARgamma transcriptional activity were evaluated. Three of these compounds showed particularly high potency toward GK, moderate activity toward PPARgamma, and their structure-activity relationships were preliminarily analyzed. The putative binding modes of one of the most promising compounds were also explored by molecular docking simulations with GK and PPARgamma. Two birds, one stone: GK/PPARgamma dual-target ligands were constructed by rational combination of pharmacophores from known GK activators and PPARgamma agonists. Their ability to induce GK and PPARgamma transcriptional activity were evaluated, and the putative binding modes of one of the most promising compounds were also explored by molecular docking simulations with GK and PPARgamma.
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Reference：
Thiazole | C3H9844NS – PubChem,
Thiazole | chemical compound | Britannica