440100-94-7,440100-94-7, 2-Bromothiazole-5-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of 2-bromothiazole-5-carbonitrile (200 mg, 1.05 mmol), tert-butylpiperazine-1-carboxylate (800 mg, 4.3 mmol), potassium phosphate tribasic (260 mg, 1.22mmol), palladium acetate trimer (40 mg, 0.06 mmol), tri-tert-butylphosphinetetrafluoroborate (20 mg, 0.06 mmol) in toluene (4 mL), taken in a microwave vial underargon atmosphere was irradiated for 30 min at 80 C (TLC indicated complete consumptionof starting material). The reaction mixture was diluted with water (10 mL) and extracted withEtOAc (3 x 30 mL). The combined organic extracts were washed with brine (10 mL), driedover N a2S04 and concentrated under reduced pressure. The crude product obtained waspurified by column chromatography (100-200 silica gel, 20 g, 10-30% EtOAc-Hexane) toafford tert-butyl 4-(5-cyanothiazol-2-yl)piperazine-1-carboxylate (200 mg, 64%) as a whitesolid LCMS (ESI+): m/z: 295.60 [M+Ht.
The synthetic route of 440100-94-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MITOBRIDGE, INC.; TAKAHASHI, Taisuke; KLUGE, Arthur; LAGU, Bharat; JI, Nan; (162 pag.)WO2018/125961; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica