The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.82294-70-0, Name is 4-Methylthiazole-5-carbaldehyde, molecular formula is C5H5NOS. In a Article，once mentioned of 82294-70-0, Recommanded Product: 4-Methylthiazole-5-carbaldehyde
The aim of this study was to design and synthesize COX-1/COX-2 balanced inhibitors incorporating the structural motifs of anti-inflammatory ascidian metabolites. We designed a series of substituted indole analogs that incorporate the key structures of the ascidian metabolites, herdmanines C and D. The synthesized analogs were tested for their inhibitory activity against COX-1 and COX-2, and compound 5m, which displayed balanced inhibition, was further evaluated for in vitro anti-inflammatory activity. Compound 5m suppressed the expression of pro-inflammatory factors, including iNOS, COX-2, TNF-alpha, and IL-6 in LPS-stimulated murine RAW264.7 macrophages. The reduction of PGE2, NO, and ROS was also observed, together with the suppression of NF-kappaB, IKK, and IkappaBalpha phosphorylation. Our results characterized 5m as a COX-1/COX-2 balanced inhibitor that subsequently caused ROS inhibition and NF-kappaB suppression, and culminated in the suppression of iNOS, COX-2, TNF-alpha, and IL-6 expression.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 4-Methylthiazole-5-carbaldehyde, you can also check out more blogs about82294-70-0
Reference：
Thiazole | C3H5733NS – PubChem,
Thiazole | chemical compound | Britannica