41731-52-6, Ethyl 2-chlorothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Sodium borohydride (690 mg, 18 mmol) was added as a single portion to a solution of ethyl 2-chloro-4-thiazolecarboxylate (1.6 g, 9 mmol) in ethanol (70 ml) at 0 C., then the mix was allowed to warm to room temperature with stirring overnight. The reaction was acidified to pH 5 with IN HCl and concentrated under vacuum, then the white residue was partitioned between water (125 ml) and ethyl acetate (3*300 ml). The organic phase was washed with brine and dried (Na2SO4), then the solvents were removed. Chromatography of the residue on silica gel (15 g, eluent 15%/-30% hexane/ethyl acetate) gave 2-chloro-4-hydroxymethylthiazole (850 mg, 5.5 mmol) in 63% yield as a clear oil, 1H nmr, 4.72 (s, 2H), 7.11 (s, 1H)., 41731-52-6
The synthetic route of 41731-52-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Biota Scientific Management Pty Ltd.; US7078403; (2006); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica