Electric Literature of 1603-91-4. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 1603-91-4, Name is 4-Methylthiazol-2-amine. In a document type is Article, introducing its new discovery.
Using a parallel synthesis approach to target a non-conserved region of the PI3K catalytic domain a pan-PI3K inhibitor 1 was elaborated to provide alpha, delta and gamma isoform selective Class I PI3K inhibitors 21, 24, 26 and 27. The compounds had good cellular activity and were selective against protein kinases and other members of the PI3K superfamily including mTOR and DNA-PK.
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Reference：
Thiazole | C3H9585NS – PubChem,
Thiazole | chemical compound | Britannica