944804-88-0, tert-Butyl 4-bromothiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
944804-88-0, A mixture of 48 (3.61g, 12.9mmol) and 70 Na2CO3 (3.4g, 32.3mmol) in DME/H2O/dioxane (240/48/48mL) was exchanged with N2 twice, and 5-chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (45a) (6.6g, 25.9mmol) and Pd(PPh3)4 (1.45g, 1.25mmol) were added to the mixture. The reaction mixture was heated to 100C and stirred for 6h under N2 atmosphere. The solid was removed by centrifugation at 3000rpm, 25C for 20min. The supernatant was concentrated and the crude product was purified by silica gel flash chromatography (eluting with ethyl acetate in petroleum ether 2-5%) to give 11 as a white solid (1.57g, yield=37%). 1H NMR (400MHz, DMSO-d6) delta 11.79 (s, 1H), 8.44 (s, 1H), 8.11 (s, 1H), 7.61 (s, 1H), 1.50 (s, 9H); LC/MS (ESI, m/z) 274.05 [M+H]+.
The synthetic route of 944804-88-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Wang, Beilei; Wu, Jiaxin; Wu, Yun; Chen, Cheng; Zou, Fengming; Wang, Aoli; Wu, Hong; Hu, Zhenquan; Jiang, Zongru; Liu, Qingwang; Wang, Wei; Zhang, Yicong; Liu, Feiyang; Zhao, Ming; Hu, Jie; Huang, Tao; Ge, Juan; Wang, Li; Ren, Tao; Wang, Yuxin; Liu, Jing; Liu, Qingsong; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 896 – 916;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica