3034-55-7, 5-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of compound fert-butyl 4-(4-((4-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)amino)pyrimidin-2-yl)piperazine-l-carboxylate (1 equiv), K3PO4 (2 equiv), 5-bromothiazole (1 equiv) and Pd(dppf)Cl2 (0.1 equiv) in dioxane water was stirred at 100C under N2 for 16 hrs. The reaction mixture was cooled down to room temperature and quenched by the addition of water, extracted with EtOAc. The combined organics were dried with Na2S04, filtered and solvent removed under reduced pressure. The residue was purified by silica gel chromatography to afford tert-butyl 4-(4-((4-(thiazol-5- yl)phenyl)amino)pyrimidin-2-yl)piperazine-l-carboxylate.
3034-55-7, As the paragraph descriping shows that 3034-55-7 is playing an increasingly important role.
Reference£º
Patent; KADMON CORPORATION, LLC; SKUCAS, Eduardas; LIU, Kevin, G.; KIM, Ji-In; POYUROVSKY, Masha, V.; MO, Rigen; (345 pag.)WO2019/45824; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica