Discovery of 2-Amino-4-methylthiazole hydrochloride

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4-(Methyl- or phenyl)-2-thiazolyl isothiocyanates were synthesized from the appropriate amine hydrochlorides by the thiophosgene method.The <4+2> cycloaddition reaction of 4-methyl-2-thiazolyl isothiocyanate with isocyanates and aldimines afforded thiazolo<3,2-a>-1,3,5-triazine derivatives. 4-Phenyl-2-thiazolyl isothiocyanate on the other hand, did not react with isocyanates.Carbodiimides were found to react with 4-methyl-2-thiazolyl isothiocyanate by a <2+2> cycloaddition to yield the substituted 1,3-thiazetidines.

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Reference:
Thiazole | C3H1975NS – PubChem,
Thiazole | chemical compound | Britannica