With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.
Step 1: ethyl 2-(2-((3-(trifluoromethyl)benzoyl)imino)-4,5,6,7-tetrahydrobenzo[d]thiazol-3(2H)-yl)acetate To a solution of 4,5,6,7-tetrahydrobenzo[d]thiazol-2-amine (200 mg, 1.297 mmol) in tetrahydrofuran (4.3 mL) were added 3-(trifluoromethyl)benzoyl chloride (324 mg, 1.56 mmol) and potassium carbonate (359 mg, 2.59 mmol). The reaction mixture was stirred at 80 C. for 5 hours and then concentrated under reduced pressure. To the resulting intermediate (0.43 mmol) were added N,N-dimethylformamide (1.5 mL) and ethyl bromoacetate (93 mg, 0.559 mmol). The reaction mixture was stirred at 80 C. for 3 hours and then cooled to room temperature. The reaction mixture was quenched with water and then extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, filtered, and then evaporated. The residue was purified with silica gel column chromatography (n-hexaneethyl acetate=41) to give 103 mg of the titled compound as a white solid (Yield: 58%). 1H NMR (CDCl3, 400 MHz) delta 12.40 (brs, 1H), 8.54 (s, 1H), 8.43 (d, 1H), 7.71 (d, 1H), 7.54 (dd, 1H), 4.90 (s, 2H), 4.24-4.30 (m, 2H), 2.59 (brs, 2H), 2.50 (brs, 2H), 1.87-1.92 (m, 4H), 1.30 (t, 3H).
2933-29-1, The synthetic route of 2933-29-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; YUHAN CORPORATION; Hur, Youn; Kim, Dong-Hyun; Kim, Eun-Kyung; Park, Jin-Hwi; Joo, Jae-Eun; Kang, Ho-Woong; Oh, Se-Woong; Kim, Dong-Kyun; Ahn, Kyoung-Kyu; US2015/11528; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica