With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38585-74-9,Thiazol-5-ylmethanol,as a common compound, the synthetic route is as follows.
L. ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate. A solution of 3.11 g (27 mmol) of 5-(hydroxymethyl)thiazole and excess N-methyl morpholine in 100 ml of methylene chloride was cooled to 0 C. and treated with 8.2 g (41 mmol) of 4-nitrophenyl chloroformate. After being stirred for 1 h, the reaction mixture was diluted with CHCl3, washed successively with 1N HCl, saturated aqueous NaHCO3, and saturated brine, dried over NaSO4, and concentrated in vacuo. The residue was purified by silica gel chromatography (SiO2, 1-2% MeOH/CHCl3, Rf=0.5 in 4% MeOH/CHCl3) to yield 5.9 g (78%) of the desired compound as a yellow solid. NMR (CDCl3) delta5.53 (s, 2H), 7.39 (dt, J=9, 3 Hz, 2H), 8.01 (s, 1H), 8.29 (dt, J=9, 3 Hz, 2H), 8.90 (s, 1H). Mass spectrum: (M+H)+ =281.
38585-74-9, As the paragraph descriping shows that 38585-74-9 is playing an increasingly important role.
Reference£º
Patent; Abbott Laboratories; US5484801; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica