3364-80-5, Thiazole-4-carboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
3.3.C 3.3[0210] (S)-3-Phenyl-N-(3-(pyridin-4-yl)isoxazol-5-yl)-2-(thiazol-4- ylmethylamino)propanamide (3.3). To a 20 ml vial were added (S)-2-amino-3-phenyl-N- (3-(pyridin-4-yl)isoxazol-5-yl)propanamide 3.3.C (40 mg, 0.13 mmole), thiazole-4- carbaldehyde (18 mg, O.lbetammole), sodium triacetoxyborohydride (55 mg, 0.26mmole) and 10 ml of DCE. The reaction was stirred at 700C for 12 hours. The crude material was partitioned between DCM and water and then purified by reverse phase preparative HLPC to give (S)-3-phenyl-N-(3-(pyridin-4-yl)isoxazol-5-yl)-2-(thiazol-4- ylmethylamino)propanamide TFA salt 3.3 as a white solid (14.2 mg, 27 percent yield). LCMS ESI (pos.) m/e: 406.1 (M+l): IH NMR (500 MHz, MeOH-J) delta ppm 9.09 (d, J=I.96 Hz, 1 H), 8.87 (br. s., 2 H), 8.27 (d, J=5.38 Hz, 2 H), 7.77 (d, J=I.96 Hz, 1 H), 7.27 – 7.35 (m, 3 H), 7.20 – 7.25 (m, 2 H) 7.07 (s, 1 H), 4.42 – 4.55 (m, 2 H), 4.35 (dd, J=8.80, 5.87 Hz, 1 H), 3.44 (dd, J=13.57, 5.99 Hz, 1 H), 3.26 (dd, J=13.69, 8.80 Hz, 1 H).
3364-80-5, As the paragraph descriping shows that 3364-80-5 is playing an increasingly important role.
Reference£º
Patent; AMGEN INC.; DU, Xiaohui; FU, Zice; HOUZE, Jonathan, B.; JIAO, Xianyun; KIM, Yong-jae; LI, Leping; LIU, Jinqian; LIZARZABURU, Mike; MEDINA, Julio; SHEN, Wang; TURCOTTE, Simon; YU, Ming; WO2010/93849; (2010); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica