A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole, molecular formula is C14H11NS. In a Article，once mentioned of 16112-21-3, Formula: C14H11NS
Benzothiazole derivatives 1-26 have been synthesized and their in vitro beta-glucuronidase potential has been evaluated. Compounds 4 (IC50 = 8.9 ± 0.25 muM), 5 (IC50 = 36.1 ± 1.80 muM), 8 (IC50 = 8.9 ± 0.38 muM), 13 (IC50 = 19.4 ± 1.00 muM), 16 (IC50 = 4.23 ± 0.054 muM), and 18 (IC 50 = 2.26 ± 0.06 muM) showed beta-glucuronidase activity potent than the standard (d-saccharic acid 1,4-lactone, IC50 = 48.4 ± 1.25 muM). Compound 9 (IC50 = 94.0 ± 4.16 muM) is found to be the least active among the series. All active analogs were also evaluated for cytotoxicity and none of the compounds showed any cytotoxic effect. Furthermore, molecular docking studies were performed using the gold 3.0 program to investigate the binding mode of benzothiazole derivatives. This study identifies a novel class of beta-glucuronidase inhibitors.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Formula: C14H11NS, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 16112-21-3, in my other articles.
Reference：
Thiazole | C3H750NS – PubChem,
Thiazole | chemical compound | Britannica