With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88982-82-5,4-Bromo-1,3-thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.
88982-82-5, Step A:4-bromothiazole-2-carboxylic acid (1, 5.0 g, 24.0 mmol)Dissolved in ethylene glycol dimethyl ether (60mL)And water (20mL),Add 3,4-methyleneoxybenzeneboronic acid (29, 6.0 g, 36.0 mmol)And anhydrous potassium carbonate (5.0 g, 36 mmol),Then tetrakis(triphenylphosphine)palladium (1.4 g, 1.2 mmol) was added.The resulting mixture is heated under nitrogen toStir at 98 C for 24 hours.TLC analysis indicated the end of the reaction.The reaction solution was cooled to room temperature.Then add water (200 mL),The pH was adjusted to 2-3 with 6M hydrochloric acid.Filtered, the filter cake is dissolved in dichloromethane,The organic layer was washed with 20 mL of saturated sodium bicarbonate solution.Divide the water layer,The aqueous layer was adjusted to pH 2-3 with a 6M hydrochloric acid solution.Filter the solid,The filter cake is washed with water to neutrality.The filter cake was dried to give compound 30 (5.0 g).Yield: 84.0%.
88982-82-5 4-Bromo-1,3-thiazole-2-carboxylic acid 15122065, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; Zhejiang Haizheng Pharmaceutical Co., Ltd.; Wang Haibo; Zheng Xiaohe; Cai Zhengjiang; Zheng Shan; Ye Zhengchun; Ma Huidan; Lin Haiming; (54 pag.)CN108623532; (2018); A;,
Thiazole | C3H3NS – PubChem
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