With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20582-55-2,Ethyl 4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
(1) A mixture was prepared by adding 2.10 g of potassium hydrogen carbonate, 44 mg of palladium chloride (II) and 205 mg of a copper bromide (I) dimethylsulfide complex to 2.20 g of 5-bromo-2-fluoronitrobenzene and the resulting mixture was suspended in 20 mL of toluene. Subsequently, a reaction mixture solution prepared by adding 2.05 g of ethyl 4-methyl-1,3-thiazole-5-carboxylate, 92.5 muL of isobutyric acid and 228 mg of di-t-butylcyclohexylphosphine to the resulting suspension was heated at 120C for 14 hours under a nitrogen atmosphere. The reaction mixture solution was celite-filtered to remove insoluble matter and water was added to the filtrate, and extraction was performed using ethyl acetate. The organic layer was washed with saline and dried and concentrated under reduced pressure. The resulting crude product was separated and purified by silica gel column chromatography to obtain 2.28 g of ethyl 2-(4-fluoro-3-nitrophenyl)-4-methyl-1,3-thiazole-5-carboxylate. ESI/MS m/e: 311.0 (M++H, C13H12FN2O4S)
20582-55-2, 20582-55-2 Ethyl 4-methylthiazole-5-carboxylate 298610, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; Teijin Pharma Limited; KAWANA, Asahi; KANAZAWA, Chikashi; TAKAHASHI, Yoshimasa; SHIRAKURA, Takashi; EP2952513; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica