72850-52-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72850-52-3,Ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
2-Chloro-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester (259 mg, 1.0mmol), sodium ethoxide (23% by weight in ethanol) (0.33 ml, 1.1 mmol) and ethanol (2ml) were heated under reflux for 2 hours. The mixture was partitioned between water andethyl acetate. The organic phase was dried over magnesium sulfate and concentrated togive the product as a yellow gum (187 mg, 70% yield). ^-NMR (400 MHz, CDC13):1.36 (3H, t, Me), 1.45 (3H, t, Me), 4.35 (2H, q, CH2), 4.55 (2H, q, CH2).
As the paragraph descriping shows that 72850-52-3 is playing an increasingly important role.
Reference£º
Patent; SYNGENTA LIMITED; WO2006/24820; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica