88982-82-5, 4-Bromo-1,3-thiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 4-bromothiazole-2-carboxylic acid 11 (25.0 mg, 0.12 mmol) in DCM (2.0 mL), oxalyl chloride (0.02 mL,0.23 mmol) was added dropwise, and then DMF (2 drops) was added. The mixture was stirred at room temperature for 2 h and concentrated, dried by vacuum. DCM(3.0 mL) was added to the mixture and the mixture was cooled to 0 C and 3-aminobenzonitrile (60.0 mg, 0.51 mmol), DIEA (0.03 mL,0.17 mmol) was added. The mixture was stirred at room temperature overnight. The subsequent mixture was concentrated under reduced pressure and extractedwith H2O/ethyl acetate. The combined organic layer was dried by Na2SO4,concentrated under reduced pressure and purified by column chromatography on silica gel (hexane/ethyl acetate = 5:1) to afford the title compound 6be (16.0 mg, 43 %) as white solid: 1H-NMR (400MHz, CDCl3) delta 9.05(s, 1H), 8.16 (d, J = 1.64 Hz, 1H),7.86 (dt, J = 7.60, 1.92 Hz, 1H),7.59 (s, 1H), 7.48 (m, 2H). 13C-NMR (100 MHz, CDCl3) delta 163.2, 156.2, 137.6, 130.2, 128.5, 126.0,124.4, 123.9, 123.0, 118.2, 113.5. LC/MS (ESI-) 305.9 (M-H)+.
88982-82-5 4-Bromo-1,3-thiazole-2-carboxylic acid 15122065, athiazole compound, is more and more widely used in various.
Reference£º
Article; Vu, Hoang Nam; Kim, Ji Young; Hassan, Ahmed H.E.; Choi, Kihang; Park, Jong-Hyun; Park, Ki Duk; Lee, Jae Kyun; Pae, Ae Nim; Choo, Hyunah; Min, Sun-Joon; Cho, Yong Seo; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 140 – 144;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica