In an article, published in an article, once mentioned the application of 2289-75-0, Name is 4,5-Dimethylthiazol-2-amine,molecular formula is C5H8N2S, is a conventional compound. this article was the specific content is as follows.Recommanded Product: 2289-75-0
The discovery and structure-activity relationship of a series of hA 2A receptor antagonists is described. Compound 28 was selected from the series as a potent and selective compound and was shown to be efficacious in an in vivo model of Parkinson’s disease. It had acceptableADME properties; however, the low intrinsic solubility of this compound was limiting for its developability, because the oral bioavailability from dosing in suspension was significantly lower than the oral bioavailability from solution dosage. As a consequence, prodrugs of 28 were prepared with dramatically increased aqueous solubility. The prodrugs efficiently delivered 28 into systemic circulation, with no detectable levels of prodrug in plasma samples. From this investigation, we selected 32 (Lu AA47070), a phosphonooxymethylene prodrug of 28, as a drug candidate.
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Reference：
Thiazole | C3H4978NS – PubChem,
Thiazole | chemical compound | Britannica