With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23056-10-2,5-Thiocyanatothiazol-2-amine,as a common compound, the synthetic route is as follows.
To a solution of Part A thiocyanate (800 mg, 5.09 mmol) and Example 1D (1.51 g, 5.09 mmol) in THF (20 mL) was added DEPBT (3.05 g, 10.18 mmol) and iPr2NEt (1.8 mL, 10.18 mmol). The reaction mixture was stirred at RT for 18 h, then was concentrated in vacuo. The residue was taken up in EtOAc and brine, and extracted with EtOAc (3¡Á). The combined organic extracts were washed with 1N aqueous HCl, H2O, 5% aqueous NaHCO3, H2O, and brine, dried (MgSO4), and concentrated in vacuo. The residue was chromatographed (SiO2; continuous gradient 10% EtOAc/Hex to 100% EtOAc/Hexane) to give Part B compound (927 mg, 42%) as an orange solid.
23056-10-2, As the paragraph descriping shows that 23056-10-2 is playing an increasingly important role.
Reference£º
Patent; Bristol-Myers Squibb Company; US2008/9465; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica