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A novel synthesis of oxindole quinazolines modified at the C4 and C7 positions via solid phase multiparallel chemistry is described. The C7 position of the quinazoline was modified by Mitsunobu reaction and the introduction of the key C4-oxindole ring was achieved at the final stage of the synthesis and constituted the cleavage step from the resin. Purification of the final products was easily achieved via SPE taking advantage of the mild basicity of the quinazoline nucleus.
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Reference：
Thiazole | C3H5560NS – PubChem,
Thiazole | chemical compound | Britannica