20949-81-9, 2-Phenylthiazole-4-carbaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
20949-81-9, COMPOUND 12.1. 38: 4-{6,7-DIMETHOXY-2-[(2-PHENYL-1,3-THIAZOL-5- YL) METHYLl-1, 2, 3, 4-TETRAHYDROISOOUINOLIN-1-YL- N- DIETHYLBENZAMIDE; INTERMEDIATE 5.1. 7 (50 mg, 0.14 mmol) and 2-phenyl-4-thiazolecarbaldehyde (51 mg, 0.27 mmol) were dissolved in 1,2-dichloroethane (2 mL) and sodium triacetoxyborohydride (115 mg, 0.54 mmol) was added. The reaction mixture was stirred at room temperature for 18 h. Resin-bound tosylhydrazine (0.27 g, 1.5 mmol/g) was added and the mixture was agitated for another 2 h. Dichloromethane and 2 M aqueous sodium hydroxide solution were added, the mixture was shaken and passed through a Whatman 1PS filter paper. The organic phase was evaporated to dryness and purified by flash chromatography to yield the product (74 mg, 0.136 mmol, quant.). 1H NMR (500 MHz, CDC13) : 1.09, 1.23 (2 brs, 6H), 2.80, 3.04, 3.28 (3 m, 6H), 3.52 (brs, 2H), 3.82, 3.90 (2 d, J 14 Hz, 2H), 3.61, 3.85 (2 s, 6H), 4.78 (s, 1H), 6.20, 6.63 (2 s, 2H), 7.35-7. 43 (m, 7H), 7.94 (d, J 7.5 Hz, 2H). (+) LRESIMS m/z 542 (100) [M+H] +.
The synthetic route of 20949-81-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica