With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2516-40-7,2-Bromobenzothiazole,as a common compound, the synthetic route is as follows.
General procedure: A 10 mL Schlenk tube equipped with a stir bar was sealed with a rubber septum,It was dried using a heat gun under reduced pressure (about 400 ¡ã C.)It was then filled with argon.Further, reduced pressure – argon filling was repeated twice to make the inside of the Schlenk tube completely under an argon atmosphere.0.5 mL of N, N’-dimethylpropyleneurea (hereinafter referred to as DMPU) as a solvent,0.71 mL of diethylzinc (1.02 M hexane solution: 1.5 eq),386.25 mg of nonafluorobutyl iodide (1.125 mmol, 2.25 eq) were sequentially added at room temperature using a syringe.Further, 0.5 mmol of 208.2 mg of dodecyl 2-iodobenzoate (0.5 mmol, 1 equivalent) as an electrophile,9.5 mg of copper iodide (0.05 mmol: 0.1 eq) was added,After replacing the rubber septum with a glass stopper, it was heated at 90 ¡ã C. for 16 hours.After allowing the reaction mixture to cool to room temperature, the reaction was stopped with 20 mL of 1 N hydrochloric acid,And extracted three times with diethyl ether having a total volume of 100 mL.The combined organic layer was washed with saturated brine,After drying with magnesium sulfate, the solvent was distilled off with a rotary evaporator.The crude product was purified by flash column chromatography (methylene chloride / hexane 1: 7)226.2 mg of the desired product was obtained (89percent, pale yellow oil)., 2516-40-7
2516-40-7 2-Bromobenzothiazole 612040, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; THE UNIVERSITY OF TOKYO; UCHIYAMA, MASANOBU; HIRANO, KEIICHI; (29 pag.)JP2015/86221; (2015); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica