Electric Literature of 82294-70-0, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 82294-70-0, C5H5NOS. A document type is Article, introducing its new discovery.
Radical bromination of 4,5-dimethylthiazole (1) was carried out using different stoichiometries of N-bromosuccinimide in the presence of 2,2′-azobisisobutyronitrile.Mono-, tri- and tetrabromo compounds 2, 5, and 6 were obtained in good yields with regioselectivity while the dibromo derivatives 3 and 4 were formed without any selectivity.Substitution at the thiazole ring occurred in the presence of silica gel or in the perfluoro ether FC-77 (C8F16O), affording the 2-bromothiazole 7.The order of reactivity observed was 5-Me > 4-Me > C-2.Structural assignment of compounds 2-7 was made by chemical correlations and NMR spectroscopy. – Keywords: Heterocycles; NBS bromination; Selective bromination; Polybrominated thiazole; Structure elucidation
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Reference：
Thiazole | C3H5737NS – PubChem,
Thiazole | chemical compound | Britannica