61291-21-2, Name is 5-Methylthiazole-2-carboxylic acid, molecular formula is C5H5NO2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 61291-21-2, Recommanded Product: 61291-21-2
Monoacylglycerol lipase (MAGL) is a major serine hydrolase that hydrolyzes 2-arachidonoylglycerol (2-AG) to arachidonic acid (AA) and glycerol in the brain. Because 2-AG and AA are endogenous biologically active ligands in the brain, inhibition of MAGL is an attractive therapeutic target for CNS disorders, particularly neurodegenerative diseases. In this study, we report the structure-based drug design of novel piperazinyl pyrrolidin-2-ones starting from our hit compounds 2a and 2b. By enhancing the interaction of the piperazinyl pyrrolidin-2-one core and its substituents with the MAGL enzyme via design modifications, we identified a potent and reversible MAGL inhibitor, compound (R)-3t. Oral administration of compound (R)-3t to mice decreased AA levels and elevated 2-AG levels in the brain.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 61291-21-2. In my other articles, you can also check out more blogs about 61291-21-2
Reference：
Thiazole | C3H6519NS – PubChem,
Thiazole | chemical compound | Britannica