Electric Literature of 15679-12-6. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 15679-12-6, Name is 2-Ethyl-4-methylthiazole. In a document type is Article, introducing its new discovery.
The palladium-catalysed direct coupling of aryl halides with heteroaromatics in greener solvents than DMF or DMAc, which are often employed for such couplings, would be a considerable advantage for both industrial application and sustainable development. We observed that a range of aryl bromides undergoe coupling via C-H bond activation/functionalisation reaction of thiazoles or imidazoles in moderate to good yields using pentan-1-ol or 3-methylbutan-1-ol as the solvents. Pentan-1-ol and 3-methylbutan-1-ol are less toxic than DMF or DMAc, moreover they are bioresources as they can be obtained by fermentation. Therefore, these reaction conditions are certainly more eco-compatible than those generally employed for such couplings.
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Reference：
Thiazole | C3H3236NS – PubChem,
Thiazole | chemical compound | Britannica