Sep 2021 News Extracurricular laboratory:new discovery of 6-(Trifluoromethyl)benzo[d]thiazol-2-amine

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In an article, published in an article, once mentioned the application of 777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine,molecular formula is C8H5F3N2S, is a conventional compound. this article was the specific content is as follows.Application In Synthesis of 6-(Trifluoromethyl)benzo[d]thiazol-2-amine

Acylaminobenzothiazole hits were identified as potential inhibitors of Trypanosoma cruzi replication, a parasite responsible for Chagas disease. We selected compound 1 for lead optimization, aiming to improve in parallel its anti-T. cruzi activity (IC50 = 0.63 muM) and its human metabolic stability (human clearance = 9.57 mL/min/g). A total of 39 analogues of 1 were synthesized and tested in vitro. We established a multiparametric structure-activity relationship, allowing optimization of antiparasite activity, physicochemical parameters, and ADME properties. We identified compound 50 as an advanced lead with an improved anti-T. cruzi activity in vitro (IC50 = 0.079 muM) and an enhanced metabolic stability (human clearance = 0.41 mL/min/g) and opportunity for the oral route of administration. After tolerability assessment, 50 demonstrated a promising in vivo efficacy.

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Reference:
Thiazole | C3H6726NS – PubChem,
Thiazole | chemical compound | Britannica