170961-15-6, tert-Butyl thiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 1; a) 2-(Tert-butoxycarbonylamino)-5-fluorothiazole; 2-(Tert-butoxycarbonylamino)thiazole (lOg, 0.050mol) in THF (0.2L) was cooled to -50C under argon. tBuLi solution in pentane (60mL of a 1.7M solution, 0.102mol, 2.05eq) was added over a period of 30min and the temperature kept below -40C. The suspension thus obtained was stirred at -50C for 30min. A solution of N-fluorobenzenesulfonimide (NFSi) was prepared (22. Og, 0.07mol in 70mL THF, 1.4eq) and 50mL of this solution (leq) was added over a 5min period and the temperature kept under -40C. The reaction was stirred for 20min at -50C. Then tBuLi (lOmL, 0.017mol, 0.35eq) and the NFSi solution (lOmL, 0.4eq) added. The solution thus obtained was stirred at -50C for 45min and then added to saturated NH4CI solution (300mL). The organic phase was separated and the aqueous phase further washed with diethylether (lOOmL). The combined organic fractions were washed with brine (20mL) solution and dried (Na2SO?}). The solvent was removed and the solid further dried to afford a brown solid. To this crude product was added trifluoroethanol (60mL) and formic acid (0.6mL). The suspension was heated to 85C until it gave a solution. The flask was then cooled to RT and the precipitate thus formed filtered off to afford, after drying under high vacuum, the title compound (6.4g, contains 2.3% of starting material according to HPLC at275nm). After a second crystallisation (trifluoroethanol (22mL) and formic acid (0.22mL),for 20min at 85C), the title compound was obtained as an off white solid (4.6g, contains 1% of starting material, 97.5% pure by HPLC). ‘HNMR (CDC13) 8: 6.90 (1H, d, CHCF), 1.60 (9H, s, Boc-H)., 170961-15-6
As the paragraph descriping shows that 170961-15-6 is playing an increasingly important role.
Reference£º
Patent; PROSIDION LIMITED; WO2006/16174; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica