With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1603-91-4,4-Methylthiazol-2-amine,as a common compound, the synthetic route is as follows.
Mix 3-bromoacetophenone (0.6 mmol, 119 mg) and p-toluenesulfonyl hydrazide (0.6 mmol, 112 mg) in toluene (10 mL), and react at 40 oC for 2 hours.Then add 2-amino-4-methylthiazole (0.4 mmol, 46 mg), Cu (NO3) 2 ¡¤ 3H2O (16 mg), and lithium t-butoxide (96 mg) to the above reaction system at 100 oC The reaction was continued for 3 hours. After the TLC detection reaction was completed, dichloromethane was added to the system, successively washed with brine and water, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and separated by column chromatography to obtain the final pure compound 3t (80%, 95.1 mg)., 1603-91-4
As the paragraph descriping shows that 1603-91-4 is playing an increasingly important role.
Reference£º
Patent; Jining Medical University; Xie Zengyang; Liu Jun; Yang Qianqian; Zhang Bo; (15 pag.)CN110229121; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica