Synthetic Route of 1603-91-4. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 1603-91-4, Name is 4-Methylthiazol-2-amine. In a document type is Article, introducing its new discovery.
The reactions of ketones and AT-substituted thioureas, in the presence of HC1 (or HBr) and DMSO afford mixtures of the title compounds which are easily separated on a silica gel column. This method avoids the classical use of a-haloketones. The mechanism of these reactions involves the enolization of ketones and the activation of thiourea sulfur, probably by oxygen transfer from DMSO.
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Reference：
Thiazole | C3H9620NS – PubChem,
Thiazole | chemical compound | Britannica